Preferred Label : Pladienolide Derivative E7107;
NCIt related terms : E7107;
NCIt definition : A synthetic urethane derivative of pladienolide D with potential antineoplastic activity.
Pladienolide derivative E7107 is generated from the 12-membered macrolide pladienolide
D, one of several macrolides derived from the bacterium Streptomyces platensis Mer-11107.
This agent appears to bind to the 130-kDa subunit 3 (spliceosome-associated protein
130; SAP130) of the splicing factor 3b (SF3b), resulting in inhibition of pre-messenger
RNA splicing and the arrest of cell-cycle progression. The splicing factor SF3b is
a multiprotein complex integral to the accurate excision of introns from pre-messenger
RNA; the subunit SAP130 associates with U2 snRNP and is recruited to prespliceosomal
complexes.;
UNII : R60DZX1E2N;
InChIKey : MNOMBFWMICHMKG-MGYWSNOQSA-N;
CAS number : 630100-90-2;
Molecule name : E7107;
Chemical formula : C40H66N2O9;
NCI Metathesaurus CUI : CL375254;
Origin ID : C69005;
UMLS CUI : C2347523;
Semantic type(s)
- concept_is_in_subset
- has_target
