Preferred Label : Sialyl Lewis-Keyhole Limpet Hemocyanin Conjugate Vaccine;
NCIt definition : A vaccine consisting of the oligosaccharide antigen sialyl Lewis (CA19-9) conjugated
to the nonspecific immunomodulator keyhole limpet hemocyanin (KLH), with potential
antineoplastic activity. Upon administration, sialyl Lewis-keyhole limpet hemocyanin
conjugate vaccine may induce production of IgG and IgM antibodies as well as trigger
an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing
the sialyl Lewis antigen. Sialyl Lewis is a blood group antigen and a tumor-associated
antigen associated with epithelial cancers such as breast cancer and various digestive
cancers. Sialyl Lewis serves as a ligand for the cytokine-inducible cell adhesion
molecule (CAM) E-selectin, an endothelial cell-specific type I transmembrane surface
protein, thus facilitating hematogenous metastasis by mediating the adhesion of circulating
cancer cells to vascular endothelium.;
NCI Metathesaurus CUI : CL375271;
Origin ID : C69000;
UMLS CUI : C2348200;
Semantic type(s)
- concept_is_in_subset
