Preferred Label : Filanesib;
NCIt synonyms : 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-,
(2S)-; KSP Inhibitor ARRY-520;
NCIt definition : A synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential
antineoplastic activity. Filanesib specifically inhibits KSP (kinesin-5 or Eg5), resulting
in activation of the spindle assembly checkpoint, induction of cell cycle arrest during
the mitotic phase, and consequently cell death in tumor cells that are actively dividing.
Because KSP is not involved in postmitotic processes, such as neuronal transport,
this agent does not cause the peripheral neuropathy that is often associated with
tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is
essential for the formation of bipolar spindles and the proper segregation of sister
chromatids during mitosis.;
UNII : 8A49OSO368;
InChIKey : LLXISKGBWFTGEI-FQEVSTJZSA-N;
CAS number : 885060-09-3;
Molecule name : ARRY-520; ARRY 520;
Codes from synonyms : 218;
Origin ID : C68937;
UMLS CUI : C4550884;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
