Preferred Label : Therapeutic Estetrol;
NCIt synonyms : Therapeutic E4; Estra-1,3,5(10)-triene-3,15,16,17-tetrol, (15alpha,16alpha,17beta)-; Estetrol (Anhydrous);
NCIt related terms : ESTETROL ANHYDROUS;
NCIt definition : A synthetic steroid similar or identical to endogenous estetrol, a short-acting estrogen
with both agonistic and antagonistic estrogen receptor activity. Administered orally,
therapeutic estetrol binds to the estrogen receptor and as a selective estrogen receptor
modulator (SERM) exhibits estrogen agonism in certain tissues and estrogen antagonism
in others. Displaying weak estrogen activity in the uterus, estetrol acts as an estrogen
antagonist in breast tissue. Produced solely by the human fetal liver, endogenous
estetrol is the primary estrogen metabolite of estrogen biosynthesis in the human
fetal liver.;
UNII : ENB39R14VF;
InChIKey : AJIPIJNNOJSSQC-NYLIRDPKSA-N;
CAS number : 15183-37-6;
NCI Metathesaurus CUI : CL374508;
Origin ID : C68928;
UMLS CUI : C2348768;
Currated CISMeF NLP mapping
- Semantic type(s)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
- concept_is_in_subset
