Preferred Label : Anti-CEA/Anti-DTPA-In (F6-734) Bispecific Antibody;
NCIt synonyms : F6-734 BsMAb; Anti-CEA Anti-DTPA-In F6-734 Bispecific Antibody;
NCIt definition : A bispecific monoclonal antibody (BsMAb) consisting of the Fab fragment of an anti-CEA
monoclonal antibody (F6) coupled to the Fab fragment of an anti-DTPA-In monoclonal
antibody (734) with potential radioimmunotherapeutic activity. In a two-step pretargeted
radioimmunotherapeutic approach, this BsMAb, localizing to CEA-expressing tumor cells
via the F6 Fab fragment, is introduced into patient first, followed by injection of
indium 131-radiolabeled DTPA, which is recognized by the 734 Fab fragment of the BsMAb.
Accordingly, a potentially lethal dose of indium 131 is delivered specifically to
CEA-expressing tumor cells while minimizing radiotoxicity to normal tissues. CEA (carcinoembryonic
antigen) is a tumor antigen overexpressed in many cancer types, including gastrointestinal,
breast, non-small cell lung, and thyroid cancers. DTPA (diethylenetriaminepentaacetic
acid) is a bivalent hapten.;
NCI Metathesaurus CUI : CL374415;
Origin ID : C68927;
UMLS CUI : C2346806;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
