Preferred Label : Therapeutic Hemin;
NCIt synonyms : Hematin for Injection; Hemin for Injection;
NCIt definition : A sterile, lyophilized powder of hemin, the Fe3 oxidation product of heme (Fe2 ),
derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic
acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway,
resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors.
The mechanism by which therapeutic hematin produces symptomatic improvement in patients
with acute episodes of the hepatic porphyrias has not been determined.;
Drug name : Panhematin;
Origin ID : C68925;
UMLS CUI : C2348769;
Manual NTBT mappings (CISMeF)
- Semantic type(s)
- concept_is_in_subset
