Preferred Label : Oral Picoplatin;
NCIt synonyms : Picoplatin (Oral);
NCIt definition : An oral preparation of picoplatin, a third generation platinum compound with antineoplastic
activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA,
forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA
replication and RNA transcription and the induction of apoptosis. Because of the increase
in steric bulk around the platinum center, there is a relative reduction in the inactivation
of picoplatin by thiol-containing species such as glutathione and metallothionein
in comparison to cisplatin.;
NCI Metathesaurus CUI : CL374343;
Origin ID : C68924;
UMLS CUI : C2347402;
Semantic type(s)
- concept_is_in_subset
