Preferred Label : Niacin;
NCIt synonyms : Vitamin B3; Nicotinic Acid; 3-Pyridinecarboxylic Acid;
NCIt related terms : Nicotinamide; Vitamin B-3; Nicotinic Acid Amide;
NCIt definition : A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal
and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active
form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide
(NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue
respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although
the exact mechanism of action by which niacin lowers cholesterol is not fully understood,
it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting
the release of free fatty acids from adipose tissue, increasing lipoprotein lipase
activity, and reducing the hepatic synthesis of VLDL-C and LDL-C.;
Alternative definition : CRCH: Water-soluble vitamin that is a cosubstrate or coenzyme with numerous dehydrogenases
for the transfer of the hydride ion. (DRI); NCI-GLOSS: A nutrient in the vitamin B complex that the body needs in small amounts
to function and stay healthy. Niacin helps some enzymes work properly and helps skin,
nerves, and the digestive tract stay healthy. Niacin is found in many plant and animal
products. It is water-soluble (can dissolve in water) and must be taken in every day.
Not enough niacin can cause a disease called pellagra (a condition marked by skin,
nerve, and digestive disorders). A form of niacin is being studied in the prevention
of skin and other types of cancer. Niacin may help to lower blood cholesterol.;
UNII : 2679MF687A;
InChIKey : PVNIIMVLHYAWGP-UHFFFAOYSA-N;
CAS number : 59-67-6;
Unit used : mg;
Chemical formula : C6H5NO2;
NSC code : 169454;
ChEBI ID : CHEBI:15940;
Codes from synonyms : CDR0000629155; CDR0000556407; CDR0000629154; 06743; NSC0015010; NSC0027452; NSC0169454;
Origin ID : C689;
UMLS CUI : C0027996;
Automatic exact mappings (from CISMeF team)
- vitamin PP [Artificial nutrition thesaurus concept]
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Niacin [ICD-11 Extension code]
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
- concept_is_in_subset
