" /> IKZF1 wt Allele - CISMeF





Preferred Label : IKZF1 wt Allele;

NCIt synonyms : hIk-1; ZNFN1A1; LYF1; PRO0758; IK1; IKAROS; Hs.54452; IKZF1; IKAROS Family Zinc Finger 1 wt Allele; IKAROS Family Zinc Finger 1 (Ikaros) Gene; PPP1R92; CVID13; LyF-1; Zinc Finger Protein, Subfamily 1A, 1 (Ikaros) Gene; Protein Phosphatase 1, Regulatory Subunit 92 Gene; Zinc Finger Protein, Subfamily 1A, Member 1 Gene;

NCIt definition : Human IKZF1 wild-type allele is located within 7p13-p11.1 and is approximately 123 kb in length. This allele, which encodes DNA-binding protein Ikaros, plays a role in transcriptional enhancement. Truncated and mutated forms of the gene can be a factor in acute lymphoblastic leukemia. A translocation t(3;7)(q27;p12) that fuses the gene to the BCL6 gene is implicated in diffuse large B-cell lymphomas.;

NCIt note : Studies revealed that IKZF1 wt allele was deleted or mutated in two independent groups of ALL patients who had high rates of relapse. Authors concluded that these patients may have a previously unrecognized subtype(s) of ALL with very poor prognosis. NCI Cancer Bulletin, Nov 2008;

GenBank Accession Number : NM_006060;

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18/05/2024


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