NCIt related terms : (4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene;
NCIt definition : An oral dietary supplement containing a natural cyclic monoterpene and major component
of the oil extracted from citrus peels with potential chemopreventive and antitumor
activities. Although the mechanism of action has yet to be fully elucidated, limonene
and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene
1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and
may induce apoptosis via the induction of the transforming growth factor beta-signaling
pathway. In addition, they inhibit post-translational modification of signal transduction
proteins, resulting in G1 cell cycle arrest as well as differential expression of
cell cycle- and apoptosis-related genes.;
Alternative definition : CRCH: A terpene with two isoprene units forming a ring. The chemical structure is
CC1 CCC(CC1)C( C)C.;
NCIt note : See 'DL-Limonene';
Concept status : Retired_Concept;
CAS number : 138-86-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 138-86-3
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