Preferred Label : Caffeic Acid;
NCIt related terms : Trans 3,4-Dihydroxycinnamic acid; (2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid;
NCIt definition : An orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential
anti-oxidant, anti-inflammatory, and antineoplastic activities. Upon administration,
caffeic acid acts as an antioxidant and prevents oxidative stress, thereby preventing
DNA damage induced by free radicals. Caffeic acid targets and inhibits the histone
demethylase (HDM) oncoprotein gene amplified in squamous cell carcinoma 1 (GASC1;
JMJD2C; KDM4C) and inhibits cancer cell proliferation. GASC1, a member of the KDM4
subgroup of Jumonji (Jmj) domain-containing proteins, demethylates trimethylated lysine
9 and lysine 36 on histone H3 (H3K9 and H3K36), and plays a key role in tumor cell
development.;
Alternative definition : CRCH: A hydrolyzable tannin with a propenoic acid (COOHCH CH-), and hydroxyl groups
at the 3 and 4 positions of the phenyl ring. The chemical structure is C1 CC( C(C
C1\\C C\\C( O)O)O)O.;
UNII : U2S3A33KVM;
InChIKey : QAIPRVGONGVQAS-DUXPYHPUSA-N;
CAS number : 331-39-5;
Chemical formula : C9H8O4;
NSC code : 57197; 623438;
ChEBI ID : CHEBI:16433; CHEBI:36281; CHEBI:17395;
Origin ID : C68540;
UMLS CUI : C0054433;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
