Mediastinal Seminoma

Preferred Label : Mediastinal Seminoma;

NCIt synonyms : Seminoma of Mediastinum; Seminoma of the Mediastinum;

NCIt definition : An extragonadal malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of uniform cells with clear or eosinophilic cytoplasm, round nucleus with one or more nucleoli, and distinct cellular borders. It usually arises from the anterior mediastinum. It may present with respiratory distress, chest pain, or superior vena cava syndrome or it may be asymptomatic, with the tumor detected on routine chest x-ray. The prognosis of mediastinal pure seminomas is favorable compared to the mediastinal non-seminomatous malignant germ cell tumors.;

Neoplastic status : Malignant;

Details

Origin ID

C6812;

UMLS CUI

C1334680;

Automatic exact mappings (from CISMeF team)
- Mediastinal seminoma [PASCAL descriptor]
- Mediastinal seminoma [MedDRA LLT]
- mediastinum seminoma [DO Concept]
DO Cross reference
- mediastinum seminoma [DO Concept]
Disease excludes abnormal cell
- Neoplastic Sex Cord-Stromal Cell [NCIt concept]
Disease may have findings
- Chest Pain [NCIt concept]
- Cough [NCIt concept]
- Hemorrhagic Change [NCIt concept]
- Hoarseness [NCIt concept]
- Necrotic Change [NCIt concept]
- Respiratory Distress [NCIt concept]
- Superior Vena Cava Syndrome [NCIt concept]
Excludes anatomical site(s)
- Gonad [NCIt concept]
- Neck [NCIt concept]
Has associated anatomic sites
- Mediastinum [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Mediastinal seminoma [MedDRA LLT]
- mediastinum seminoma [DO Concept]
concept_is_in_subset
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Germ Cell [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
- Malignant Germinomatous Cells Present [NCIt concept]
disease_has_normal_cell_origin
- Germ Cell [NCIt concept]
disease_has_normal_tissue_origin
- Germinal Layer [NCIt concept]
disease_has_primary_anatomic_site
- Mediastinum [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 12p [NCIt concept]
- i(12p) [NCIt concept]
disease_may_have_molecular_abnormality
- C-KIT Tyrosine Kinase Protein Overexpression [NCIt concept]
- KIT Gene Mutation [NCIt concept]

Keyword's position in hierarchy(ies) :

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