Preferred Label : Maytansine-Site Binding Agent;
NCIt synonyms : Rhizoxin-Site Binding Agent;
NCIt definition : Any of a class of anti-mitotic compounds that bind to the maytansine site of the beta
tubulin subunit, a region that appears to overlap, at least partially, with the vinca-binding
site. Compared to the vinca-site binding agents, these ligands have distinctly different
chemical structures, resulting in unique interactions with the sulfhydryl residues,
and perhaps with other structures on the tubulin protein, thereby producing different
physiological effects which do not fully mimic those of the vinca-site ligands. Like
the vinca-site agents, these compounds inhibit the polymerization of tubulin dimers
and thereby, prevent the assembly of microtubules. The subsequent decrease in the
amount of formed microtubules causes disassembly of the mitotic spindle resulting
from instability of the structure during the mitotic interphase, eventually leading
to cell cycle arrest and/or apoptosis.;
Origin ID : C67477;
UMLS CUI : C1881632;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
