Preferred Label : Taxane-Pocket Binding Agent;
NCIt synonyms : Taxane-Site Binding Agent;
NCIt definition : Any of a class of anti-mitotic compounds that bind to the taxane site of the beta-tubulin
subunit, a region described as a binding pocket located within the middle domain and
corresponding to an approximate residue sequence of 217-231. Specifically, these agents
bind to a cysteine residue within the pocket, which is also the binding site for GTP.
Agents binding at the taxane site promote the polymerization of dimers to form a very
rigid and stable microtubule structure which is not readily disassembled. By interfering
with microtubule dynamics these agents inhibit the normal turnover process essential
during mitosis, thereby causing cell-cycle arrest and/or apoptosis.;
Origin ID : C67437;
UMLS CUI : C1883268;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
