Preferred Label : Vinca-Domain Binding Agent;
NCIt synonyms : Vinca-Site Binding Agent; Vinca-Domain Binding Agents; Vinca-Site Binding Agents;
NCIt definition : Any of a class of anti-mitotic compounds that bind to the vinca site of the beta tubulin
subunit, a region located within the middle domain of the tubulin structure and corresponding
with a residue sequence approximating 177-215. The agent binds to the vinca site to
produce a conformational change in the protofilament structure and at high concentrations,
to induce the formation of spirals and crystal aggregates; these changes impair the
polymerization of tubulin dimers and thereby, prevent the assembly of microtubules.
The subsequent decrease in the amount of formed microtubules causes disassembly of
the mitotic spindle resulting from instability of the structure during the mitotic
interphase, eventually leading to cell cycle arrest and/or apoptosis. Vinca-site binding
agents include natural compounds isolated from the periwinkle (Catharanthus roseus,
formally, Vinca roseus) plant and synthetic compounds.;
Origin ID : C67422;
UMLS CUI : C1883533;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
