Preferred Label : Colchicine-Site Binding Agent;
NCIt synonyms : Colchicine-Site Binding Agents;
NCIt definition : An anti-mitotic compound that binds to the beta tubulin subunit at the N-terminal
domain (within residues 1-41) and within residues 214-241. Agents binding at the colchicine
site produce a conformational change in the protofilament structure which subsequently
impairs the polymerization of tubulin dimers and thereby prevents the formation of
microtubules. The subsequent decrease in the amount of formed microtubules causes
disassembly of the mitotic spindle resulting from instability of the structure during
the mitotic interphase, leading to cell cycle arrest and/or apoptosis.;
Origin ID : C67421;
UMLS CUI : C1880116;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
