Preferred Label : Baclofen/Amitriptyline/Ketamine Gel;
NCIt synonyms : BAK Gel; Baclofen Amitriptyline Ketamine Gel;
NCIt definition : A topical preparation of baclofen, amitriptyline, and ketamine compounded in a penetration-enhancing
polaxamer-lecithin organogel (PLO) with potential antineuralgic activity. The gamma-aminobutyric
acid (GABA) analogue baclofen appears to activate the inhibitory GABA(B) receptor,
a G protein-coupled receptor, which may result in hyperpolarization of the neuronal
cell membrane and inhibition of neurotransmitter release. Amitriptyline likely produces
antineuralgic effects via modulation of multiple subtypes of glutamate (Glu) receptors,
independent of its antidepressant actions. Ketamine displays complex pharmacologic
actions including biogenic amine uptake inhibition, interaction with opioid receptors,
and inhibition of N-methyl D-aspartate (NMDA) receptors. Stimulation of GABA(B) receptor
activity, modulation of Glu receptor activity, and inhibition of NMDA receptor activity
may be of benefit in managing neuropathic pain.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of peripheral neuropathy (pain,
numbness, tingling, burning, or weakness in the hands or feet) caused by chemotherapy.
It contains three drugs, baclofen, amitriptyline, and ketamine, that relax muscles
by blocking nerve receptors. The gel is applied to the skin of affected areas. It
is a type of analgesic.;
Codes from synonyms : CDR0000589338; CDR0000561431;
Origin ID : C67261;
UMLS CUI : C1879777;
Semantic type(s)
- concept_is_in_subset
