Preferred Label : Ketamine/Amitriptyline NP-H Cream;
NCIt synonyms : Ketamine 2%/Amitriptyline 4% Cream; EpiCept-NP-H Cream; Ketamine Amitriptyline NP-H Cream;
NCIt definition : A topical preparation containing the antidepressant amitriptyline and the excitatory
amino acid antagonist ketamine with potential topical analgesic activity. In addition
to activating adenosine A1 receptors and inhibiting the neuronal reuptake of norepinephrine
and serotonin, amitriptyline produces antinociceptive effects, which appear to be
mediated through the modulation of multiple subtypes of glutamate receptors including
the N-methyl D-aspartate (NMDA) receptor. Ketamine inhibits biogenic amine uptake,
agonistically binds to mu-opioid receptors, and inhibits NMDA receptors. NDMA receptor
antagonists such as amitriptyline and ketamine interfere with the role of NMDA receptors
in the process of central sensitization in which NMDA receptors on spinal dorsal horn
neurons are activated, resulting in an increase in synaptic efficacy and so an amplification
of the response to sensory input.;
NSC code : 744013;
PubMed : 16202956;
Origin ID : C67250;
UMLS CUI : C1881304;
Semantic type(s)
- concept_is_in_subset
