Oncogenic Osteomalacia

Preferred Label : Oncogenic Osteomalacia;

NCIt definition : A paraneoplastic disorder affecting the skeletal system. It associated with one of four tumor types: phosphaturic mesenchymal tumor, mixed connective tissue type; osteoblastoma-like tumor; ossifying fibroma-like tumor or non-ossifying fibroma-like tumor. These neoplasms secrete fibroblast growth factor 23, which in addition to causing decreased renal phosphate reabsorption also affects the expression of 25-hydroxy-1-alpha-hydroxylase resulting in poor bone mineralization. Clinical signs include fractures, bone pain and muscle weakness. Once lesions are detected, prognosis is extremely favorable as resection most often results in cure.;

Details

Origin ID

C67235;

UMLS CUI

C1274103;

Automatic exact mappings (from CISMeF team)
- Oncogenic osteomalacia [MedDRA LLT]
Currated CISMeF NLP mapping
- Oncogenic osteomalacia [MeSH concept]
- Oncogenic osteomalacia [ORDO Disease]
- Osteomalacia due to neoplastic disease (disorder) [SNOMED CT concept]
- oncogenic osteomalacia [Disease (Nov.)]
- oncogenic osteomalacia [MeSH Supplementary Concept]
Has associated anatomic sites
- Bone [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Musculoskeletal System [NCIt concept]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Oncogenic osteomalacia [MeSH concept]
- Oncogenic osteomalacia [ORDO Disease]
- Oncogenic osteomalacia [MedDRA LLT]
- Osteomalacia due to neoplastic disease (disorder) [SNOMED CT concept]
- oncogenic osteomalacia [MeSH Supplementary Concept]
- oncogenic osteomalacia [Disease (Nov.)]
disease_has_associated_disease
- Appendicular Skeleton Phosphaturic Mesenchymal Tumor [NCIt concept]
- Benign Phosphaturic Mesenchymal Tumor [NCIt concept]
- Head and Neck Phosphaturic Mesenchymal Tumor [NCIt concept]
- Malignant Phosphaturic Mesenchymal Tumor [NCIt concept]
- Phosphaturic Mesenchymal Tumor [NCIt concept]
disease_has_finding
- Hypophosphatemia [NCIt concept]
- Phosphaturia [NCIt concept]
disease_has_normal_tissue_origin
- Connective and Soft Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone [NCIt concept]

Keyword's position in hierarchy(ies) :

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