NCIt definition : A uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing
properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate
the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition
of DNA repair and the induction of apoptosis. In addition, this agent may inhibit
the expression of STAT3 (signal transducer and activator of transcription 3), which
may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU
has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and
DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU
treatment result in the decrease or prevention of chemoresistance. In addition, this
agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells
towards a pancreatic cancer cell line in vitro.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of infections caused
by herpesvirus, including herpes-zoster (shingles). It belongs to the family of drugs
called antivirals.;