Preferred Label : Cell Cycle Checkpoint/DNA Repair Antagonist IC83;
NCIt definition : A proprietary agent with potential antineoplastic activity. IC83 appears to target
cell cycle checkpoint/DNA repair enzymes, which are involved in the recognition and
repair of damaged DNA and are overexpressed in many types of cancer cells. Inhibition
of cell cycle checkpoint/DNA repair enzymes may enhance the cytotoxicity of DNA damaging
agents and dissipate tumor cell resistance to chemotherapy and radiation therapy.;
Molecule name : IC83;
Origin ID : C67075;
UMLS CUI : C1881108;
Semantic type(s)
- concept_is_in_subset
