" /> Quinacrine Hydrochloride - CISMeF





Preferred Label : Quinacrine Hydrochloride;

NCIt synonyms : Mepacrine Dihydrochloride; Atabrine Dihydrochloride; 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine Dihydrochloride; Quinacrine Dihydrochloride;

NCIt definition : The dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.;

UNII : G6242H2NAA;

InChIKey : RZFNKJVCPDLQQA-UHFFFAOYSA-N;

CAS number : 6151-30-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 6151-30-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SN 390;

Chemical formula : C23H30ClN3O.2ClH.2H2O;

NCI Metathesaurus CUI : CL550623;

NSC code : 14229;

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11/05/2024


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