Preferred Label : HSV-TK-Transduced Donor Lymphocytes;
NCIt synonyms : HSV-TK Engineered Donor Lymphocytes; HSVTK Retrovirally-transduced Donor T Lymphocytes; HSV-TK Transduced Donor Lymphocytes;
NCIt definition : A preparation of donor lymphocytes transduced with the suicide gene herpes simplex
virus thymidine kinase (HSV-TK) with potential immunomodulating activity. Administration
of HSV-TK-transduced lymphocytes after T cell-depleted allogeneic stem cell transplantation
allows an early controllable immune reconstitution, which takes advantage of the antitumor
effect of donor lymphocytes and helps to mitigate the risk of post-transplant opportunistic
infection. To control graft-versus-host disease (GvHD) due to donor lymphocyte infusion,
HSV-TK-transduced donor lymphocytes are selectively eliminated by administration of
the antiviral agent ganciclovir. Ganciclovir, a prodrug, is readily phosphorylated
by the suicide gene HSV-TK within HSV-TK-transduced lymphocytes to its monophosphate
form and, subsequently, converted into its active triphosphate form, which specifically
kills HSV-TK- transduced donor lymphocytes.;
Origin ID : C67047;
UMLS CUI : C1881029;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
