Preferred Label : Fas Receptor Agonist APO010;
NCIt synonyms : APO010;
NCIt definition : A recombinant, soluble, hexameric fusion protein consisting of three human Fas ligand
(FasL) extracellular domains fused to the dimer-forming collagen domain of human adiponectin
with potential pro-apoptotic and antineoplastic activities. Assembled into a soluble
hexameric structure mimicking the ligand clustering of endogenous active FasL, Fas
receptor agonist APO010 activates the Fas receptor, resulting in caspase-dependent
apoptosis in susceptible tumor cell populations. FasL is a transmembrane protein of
the tumor necrosis factor (TNF) superfamily and a pro-apoptotic ligand for the death
receptor Fas.;
Drug name : Mega-FasLigand;
Origin ID : C67041;
UMLS CUI : C1879517;
Semantic type(s)
- concept_is_in_subset
