Preferred Label : Lutetium Lu-177 Capromab;
NCIt synonyms : Lutetium Lu 177-Labeled Capromab; 177Lu-meO-DOTA-7E11; Lutetium Lu 177 Monoclonal Antibody 7E11;
NCIt definition : A radioimmunoconjugate consisting of capromab linked to lutetium Lu 177 via the bifunctional
macrocyclic chelator methoxy-tetraazacyclododecane-tetraacetic acid (MeO-DOTA) with
potential antineoplastic activity. Lutetium Lu 177-capromab binds to human prostate
specific membrane antigen (PSMA) expressed on tumor cell surfaces via its capromab
moiety and, upon internalization, delivers cytotoxic beta radiation directly to PSMA-expressing
tumor cells. PSMA is a cell surface glycoprotein abundantly expressed by prostate
epithelium and is typically overexpressed by prostate cancer cells.;
Molecule name : CYT-500;
Origin ID : C67039;
UMLS CUI : C1881486;
Semantic type(s)
- concept_is_in_subset
