Preferred Label : Tergenpumatucel-L;
NCIt synonyms : Alpha-1 3-Galactosyltransferase-Expressing Allogeneic Lung Tumor Cell Vaccine;
NCIt definition : An allogeneic lung cancer vaccine with potential immunostimulating and antineoplastic
activities. Derived from allogeneic lung tumor cells, tergenpumatucel-L is engineered
to express the murine alpha-1,3-galactosyltransferase (GalT), an enzyme humans lack.
GalT catalyzes the expression of foreign alpha-1,3-galactosyl (alpha-gal) carbohydrate
epitopes in glycoproteins and in glycolipids on the cell membranes of the allogeneic
lung tumor cells present in the vaccine, essentially producing a 'xenograft'. The
hyperacute rejection involves pre-existing human anti-alpha-gal antibodies that bind
the foreign alpha-gal epitopes expressed by the vaccine tumor cell xenograft, resulting
in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity
(ADCC) towards endogenous lung tumor cells with unmodified carbohydrate epitopes.;
Drug name : Hyperacute Lung Cancer Vaccine;
PubMed : 15161001;
Origin ID : C66985;
UMLS CUI : C4086897;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
