Preferred Label : Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104;
NCIt definition : An allogeneic human cytotoxic T-lymphocyte cell line (TALL-104) with potential antineoplastic
activity. TALL-104 is an IL-2-dependent human leukemic T cell line, expressing CD8
and T-cell receptor CD3, but not CD16. Because these cells are endowed with MHC-non-restricted
killer activity, TALL-104 has destructive potential against a broad range of tumors,
while sparing normal cells. Upon administration, TALL-104 targets and interacts with
tumor cells and activates apoptotic and necrotic pathways, eventually leading to lysis
of tumor cells. In addition, TALL-104 may induce secretion of various cytokines, such
as interferon-gamma, thereby potentially enhancing the cytotoxic activity.;
Molecule name : TALL-104;
Origin ID : C66980;
UMLS CUI : C1832042;
Semantic type(s)
- concept_is_in_subset
