Preferred Label : Lutetium Lu-177 Girentuximab;
NCIt synonyms : Lutetium Lu-177-DOTA-Chimeric Monoclonal Antibody cG250; Lutetium-177 Labeled cG250; 177Lu-DOTA-cG250; Lutetium Lu 177-DOTA-Chimeric Monoclonal Antibody cG250;
NCIt definition : A radioimmunoconjugate consisting of the chimeric monoclonal antibody cG250 linked
to the low energy beta-emitting radioisotope Lutetium 177, via the bifunctional macrocyclic
chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), with potential antineoplastic
activity. The antibody moiety of lutetium Lu-177-DOTA-chimeric monoclonal antibody
cG250 binds to renal cell carcinoma (RCC) cells expressing the RCC-associated antigen
G250; a cytotoxic dose of beta radiation is selectively delivered to G250-expressing
RCC cells upon internalization of the radioimmunoconjugate.;
Origin ID : C66978;
UMLS CUI : C1881485;
Semantic type(s)
- concept_is_in_subset
