Tibolone - CISMeF

Preferred Label : Tibolone;

NCIt definition : A synthetic anabolic steroid with estrogenic, androgenic and progestagenic activities. The 3alpha- and 3beta-hydroxy metabolites of tibilone activate estrogenic receptors (ERs) in bone and vaginal tissue leading to a decrease in bone turnover, and decreased vaginal dryness, respectively; derived from the 3beta-hydroxy metabolite, its delta4-isomer activates androgenic receptors (ARs) in the brain and liver and progestogenic receptors (PRs) in endometrial tissue, affecting sexual function, lipid metabolism, and endometrial function, respectively. In breast and endometrial tissue, tibolone metabolites inhibit sulfatase, preventing the conversion of circulating estrone sulfate and estradiol sulfate to estrone and estradiol, respectively; estrogen-mediated effects in the breast and uterus are thus reduced.;

UNII : FF9X0205V2;

InChIKey : WZDGZWOAQTVYBX-XOINTXKNSA-N;

CAS number : 5630-53-5;

Drug name : Livial; Xyvion;

Molecule name : ORG OD 14;

Chemical formula : C21H28O2;

ChEBI ID : CHEBI:32223;

Details

Origin ID

C66955;

UMLS CUI

C0076660;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tibolone (medicinal product) [SNOMED CT concept]
- Tibolone (substance) [SNOMED CT concept]
- tibolone [ATC Code]
- tibolone [Substance BNPC]
- tibolone [MeSH concept]
- tibolone [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- tibolone [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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