Crolibulin - CISMeF

Preferred Label : Crolibulin;

NCIt synonyms : Microtubule Inhibitor EPC2407;

NCIt definition : A small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.;

UNII : 9ENT43KY91;

InChIKey : JXONINOYTKKXQQ-CQSZACIVSA-N;

CAS number : 1000852-17-4;

Molecule name : EPC2407;

Chemical formula : C18H17BrN4O3;

Details

Origin ID

C66938;

UMLS CUI

C1880474;

Currated CISMeF NLP mapping
- crolibulin [MeSH concept]
- crolibulin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- crolibulin [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Tubulin [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Microtubule Polymerization [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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