Dapsone Gel - CISMeF

Preferred Label : Dapsone Gel;

NCIt synonyms : Dapsone Gel, 5%; 5% Dapsone Gel;

NCIt definition : The 5% gel preparation of dapsone, a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.;

Drug name : Aczone Gel;

Details

Origin ID

C66931;

UMLS CUI

C1639494;

Currated CISMeF NLP mapping
- Product containing precisely dapsone 50 milligram/1 gram conventional release cutaneous gel (clinical drug) [SNOMED CT concept]
Semantic type(s)
- Clinical Drug [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing precisely dapsone 50 milligram/1 gram conventional release cutaneous gel (clinical drug) [SNOMED CT concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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