Preferred Label : Angiotensin II Receptor Antagonist;
NCIt synonyms : Angiotensin Receptor Blockers; Angiotensin II Receptor Antagonists; Angiotensin II Receptor Blocker; ARB;
NCIt related terms : Angiotensin II receptor blocker (ARB) medication;
NCIt definition : A class of agents that act by selectively inhibiting angiotensin II receptor activation
in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind
to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing
production and secretion of aldosterone, amongst other actions. The combined effects
result in reduction of blood pressure. Although this class of agents is also used
in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure,
it is primarily used for the treatment of hypertension in cases where the patient
is intolerant of ACE inhibitor therapy.;
Alternative definition : NICHD: A pharmaceutical agent that selectively inhibits angiotensin II receptor activation
in the renin-angiotensin-aldosterone system reducing production and secretion of aldosterone,
amongst other actions. The combined effects result in reduction of blood pressure.
It is primarily used for the reduction of proteinuria and the treatment of hypertension
in cases where the patient is intolerant of ACE inhibitor therapy.; ACC/AHA: An angiotensin receptor blocker (ARB) medication, a class of agents that
act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone
system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin
II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone,
among other actions. The combined effects result in reduction of blood pressure. It
is primarily used for the treatment of hypertension or HF.;