Preferred Label : Adult Granulosa Cell Tumor;
NCIt synonyms : Adult Type Granulosa Cell Tumor;
NCIt related terms : Granulosa cell tumor, adult type;
NCIt definition : A low-grade malignant sex cord-stromal tumor occurring in the ovary and rarely in
the testis. It is composed of granulosa cells in an often fibrothecomatous stroma.
The neoplastic cells may form various patterns including the microfollicular, which
is characterized by the presence of Call-Exner bodies, macrofollicular, insular, trabecular,
and diffuse pattern. In females, it affects middle aged to post-menopausal women.
Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic
and rarely androgenic manifestations may be present. The vast majority of cases present
as stage I tumors; however, all tumors have a potential for aggressive clinical course.
In males, it is reported in the age range of 16-76 years and the average age at presentation
is 44 years. A minority of patients have gynecomastia. Metastases have been reported
in a minority of patients.;
Neoplastic status : Malignant;
ICD-O code : 8620/1;
Origin ID : C66750;
UMLS CUI : C1879643;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Disease excludes abnormal cell
- Disease may have findings
- Has associated anatomic sites
- Semantic type(s)
- concept_is_in_subset
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_may_have_molecular_abnormality
