Preferred Label : Amifostine Anhydrous;
NCIt synonyms : Ethiofos Anhydrous; S-(2-((3-Aminopropyl)amino)ethyl) Dihydrogen Phosphorothioate; Amifostine Base;
NCIt related terms : amifostine;
NCIt definition : A phosphorylated aminosulfhydryl compound with cytoprotective activity. Amifostine
is dephosphorylated by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite
in the body. The thiol metabolite binds to and detoxifies cytotoxic platinum-containing
metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing
radiation. The elevated activity of this agent in normal tissues results from both
the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity
of normal tissues compared to tumor tissues.;
Alternative definition : NCI-GLOSS: A drug used as a chemoprotective drug to control some of the side effects
of chemotherapy and radiation therapy.;
UNII : ILA426L95O;
InChIKey : JKOQGQFVAUAYPM-UHFFFAOYSA-N;
CAS number : 20537-88-6;
Molecule name : YM-08310;
Chemical formula : C5H15N2O3PS;
ChEBI ID : CHEBI:2636;
Codes from synonyms : 00699; CDR0000045250;
Origin ID : C66724;
UMLS CUI : C3537278;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
