Amifostine Anhydrous

Preferred Label : Amifostine Anhydrous;

NCIt synonyms : Ethiofos Anhydrous; S-(2-((3-Aminopropyl)amino)ethyl) Dihydrogen Phosphorothioate; Amifostine Base;

NCIt related terms : amifostine;

NCIt definition : A phosphorylated aminosulfhydryl compound with cytoprotective activity. Amifostine is dephosphorylated by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite in the body. The thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.;

Alternative definition : NCI-GLOSS: A drug used as a chemoprotective drug to control some of the side effects of chemotherapy and radiation therapy.;

UNII : ILA426L95O;

InChIKey : JKOQGQFVAUAYPM-UHFFFAOYSA-N;

CAS number : 20537-88-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 20537-88-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : YM-08310;

Chemical formula : C5H15N2O3PS;

ChEBI ID : CHEBI:2636;

Codes from synonyms : 00699; CDR0000045250;

Details

Origin ID

C66724;

UMLS CUI

C3537278;

Currated CISMeF NLP mapping
- Amifostine (substance) [SNOMED CT concept]
- amifostine [ATC Code]
- amifostine [MeSH Descriptor]
- amifostine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- amifostine anhydrous [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients