Preferred Label : Zolasartan;
NCIt definition : A nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Zolasartan
selectively competes with angiotensin II for the binding of the angiotensin II (AT1)
receptor subtype 1 in vascular smooth muscle, thereby blocking angiotensin II-mediated
vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect
on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone
synthesis and secretion by the adrenal cortex. This blocks the effects of aldosterone
leading to an increase in sodium excretion and water and eventually a reduction in
plasma volume and blood pressure.;
UNII : 6NA6UHB9SW;
InChIKey : FIKYECRHLXONOX-UHFFFAOYSA-N;
CAS number : 145781-32-4;
Molecule name : GR 117289;
Chemical formula : C24H20BrClN6O3;
Origin ID : C66702;
UMLS CUI : C1883606;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
