Telbivudine - CISMeF

Preferred Label : Telbivudine;

NCIt synonyms : Beta-L-Thymidine; 1-(2-Deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; L-dT; Epavudine; L-Thymidine; LdT;

NCIt definition : A synthetic thymidine nucleoside analogue with antiviral activity highly specific for the treatment of hepatitis B virus (HBV). Intracellularly, telbivudine is phosphorylated to its active metabolite, telbivudine triphosphate. The dideoxy telbivudine triphosphate competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). This results in the blockade of HBV DNA replication and viral propagation.;

UNII : 2OC4HKD3SF;

InChIKey : IQFYYKKMVGJFEH-CSMHCCOUSA-N;

CAS number : 3424-98-4;

Drug name : Tyzeka;

Molecule name : NB 02B; NV-02B; LDT600;

Chemical formula : C10H14N2O5;

ChEBI ID : CHEBI:63624;

Details

Origin ID

C66584;

UMLS CUI

C1453933;

Automatic exact mappings (from CISMeF team)
- luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity [GO term]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing telbivudine (medicinal product) [SNOMED CT concept]
- Telbivudine [MeSH Descriptor]
- Telbivudine [LOINC component]
- Telbivudine (substance) [SNOMED CT concept]
- telbivudine [ATC Code]
- telbivudine [MeSH concept]
Validated automatic mappings to BTNT
- telbivudine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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