Silver Sulfadiazine

Preferred Label : Silver Sulfadiazine;

NCIt synonyms : Sulfadiazine Silver;

NCIt definition : A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.;

UNII : W46JY43EJR;

InChIKey : UEJSSZHHYBHCEL-UHFFFAOYSA-N;

CAS number : 22199-08-2;

Drug name : Flamazine; SSD; Thermazene; Silvadene; Sliverex;

Chemical formula : C10H9N4O2S.Ag;

ChEBI ID : CHEBI:9142;

Details

Origin ID

C66567;

UMLS CUI

C0037134;

Automatic exact mappings (from CISMeF team)
- Shwachman-Diamond syndrome [ORDO Disease]
- home care services [MeSH Descriptor]
See also inter- (CISMeF)
- Product containing silver sulfadiazine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- (4-amino-n-pyrimidin-2-ylbenzenesulphonamidato-nn,o1)silver [Substance BNPC]
- Product containing silver sulfadiazine (medicinal product) [SNOMED CT concept]
- Silver sulfADIAZINE [LOINC component]
- Silver sulfadiazine [ICD-11 Extension code]
- Silver sulfadiazine (substance) [SNOMED CT concept]
- silver sulfadiazine [ATC Code]
- silver sulfadiazine [SNOMED Notion]
- silver sulfadiazine [MeSH concept]
- silver sulfadiazine [MeSH Descriptor]
Validated automatic mappings to BTNT
- silver sulfadiazine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Sulfadiazine [NCIt concept]
is_salt_form_of
- Sulfadiazine [NCIt concept]

Keyword's position in hierarchy(ies) :

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