Spirapril - CISMeF

Preferred Label : Spirapril;

NCIt definition : A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spiraprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : 96U2K78I3V;

InChIKey : HRWCVUIFMSZDJS-SZMVWBNQSA-N;

CAS number : 83647-97-6;

Chemical formula : C22H30N2O5S2;

Details

Origin ID

C66560;

UMLS CUI

C0075007;

Automatic exact mappings (from CISMeF team)
- Spirapril [ICHI extension code]
- spiraprilat [MeSH Supplementary Concept]
CISMeF manual mappings
- Spirapril (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Spirapril [ICD-11 Extension code]
- Spirapril (substance) [SNOMED CT concept]
- spirapril [ATC Code]
- spirapril [MeSH concept]
- spirapril [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- spirapril [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Spirapril Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Spirapril Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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