NCIt definition : The orally available active prodrug of ICRF-154, a bisdioxopiperazine derivative,
with cardioprotective and antineoplastic activities. Like other ICRF compounds, sobuzoxane
and its active metabolite ICRF-154 interfere with topoisomerase II activity prior
to the formation of intermediate cleavable DNA-enzyme complexes during the catalytic
cycle resulting in tumor cell growth inhibition. Furthermore, sobuzoxane chelates
metal cations thereby limiting the formation of free radical-generating anthracycline-metal
complexes and may prevent anthracycline-induced oxidative damage to cardiac and soft
tissues.;