Sobuzoxane - CISMeF

Preferred Label : Sobuzoxane;

NCIt synonyms : 1,2-Bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane;

NCIt definition : The orally available active prodrug of ICRF-154, a bisdioxopiperazine derivative, with cardioprotective and antineoplastic activities. Like other ICRF compounds, sobuzoxane and its active metabolite ICRF-154 interfere with topoisomerase II activity prior to the formation of intermediate cleavable DNA-enzyme complexes during the catalytic cycle resulting in tumor cell growth inhibition. Furthermore, sobuzoxane chelates metal cations thereby limiting the formation of free radical-generating anthracycline-metal complexes and may prevent anthracycline-induced oxidative damage to cardiac and soft tissues.;

UNII : R1308VH37P;

InChIKey : OCOKWVBYZHBHLU-UHFFFAOYSA-N;

CAS number : 98631-95-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 98631-95-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MST-16;

Chemical formula : C22H34N4O10;

Details

Origin ID

C66540;

UMLS CUI

C0378253;

Currated CISMeF NLP mapping
- sobuzoxane [MeSH concept]
- sobuzoxane [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- sobuzoxane [MeSH concept]
- sobuzoxane [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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