NCIt definition : An orally available, piperazine derivative with anti-anginal and potential antineoplastic
activities. Ranolazine's mechanism of action for its anti-ischemic effects has yet
to be fully elucidated but may involve the alteration of the trans-cellular late sodium
current in the ischemic myocyte. By preventing the rise of intracellular sodium levels,
ranolazine may affect the transport activity of sodium-dependent calcium channels
and prevent the calcium overload during myocardial ischemia, thereby preventing cellular
injury. Ranolazine's potential antineoplastic effect may depend on its inhibitory
effect on fatty acid oxidation, which may sensitize tumor cells to apoptosis and decrease
tumor cell proliferation; fatty acid oxidation provides energy and promotes tumor
cell proliferation and survival.;
UNII : A6IEZ5M406;
InChIKey : XKLMZUWKNUAPSZ-UHFFFAOYSA-N;
CAS number : 95635-55-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 95635-55-5
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