Preferred Label : Pyrvinium Pamoate;
NCIt synonyms : Quinolinium, 6-(Dimethylamino)-2-(2-(2,5-dimethyl-1-phenyl-1h-pyrrol-3-yl)ethenyl)-1-methyl-,
Salt with 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic Acid) (2:1); 6-(Dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-methylquinolinium
4,4'-methylenebis(3-hydroxy-2-naphthoate) (2:1);
NCIt definition : The pamoate salt of pyrvinium, a quinoline-derived cyanine dye and an mitochondrial
oxidative phosphorylation (OxPhos) inhibitor, with anthelmintic and potential antineoplastic
activities. Upon administration, pyrvinium pamoate may inhibit mitochondrial OxPhos
and mitochondrial respiration, decreases mitochondrial function, prevents tumor cell
metabolism and deprives tumor cells of energy, thereby preventing tumor cell proliferation
and leading to tumor cell death in some types of cancer cells. Mitochondrial OxPhos
is overactivated in cancer cells and plays a key role in tumor cell proliferation.
Drug resistant tumor cells are very susceptible to decreased mitochondrial OxPhos
as they cannot easily compensate for the decrease in mitochondrial function by increasing
glycolysis.;
UNII : 310X6S84LW;
InChIKey : OOPDAHSJBRZRPH-UHFFFAOYSA-N;
CAS number : 3546-41-6;
Chemical formula : 2C26H28N3.C23H14O6;
Origin ID : C66499;
UMLS CUI : C0139597;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
