Pivampicillin Probenate

Preferred Label : Pivampicillin Probenate;

NCIt definition : The probenate salt form of pivampicillin, a semisynthetic, orally active pivalate ester of ampenicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and eventually causing cell lysis.;

UNII : M3MYK6R22U;

InChIKey : LKZFWYIOFQDUMO-GLCLSGQWSA-N;

CAS number : 42190-91-0;

Chemical formula : C22H29N3O6S.C13H19NO4S;

Details

Origin ID

C66441;

UMLS CUI

C0605353;

Currated CISMeF NLP mapping
- Pivampicillin probenate [SMS substance]
- pivampicillin probenate [MeSH concept]
- pivampicillin probenate [MeSH Supplementary Concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- pivampicillin probenate [MeSH concept]
- pivampicillin probenate [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Pivampicillin [NCIt concept]
is_salt_form_of
- Pivampicillin [NCIt concept]

Keyword's position in hierarchy(ies) :

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