Piridronic Acid

Preferred Label : Piridronic Acid;

NCIt synonyms : 2-(2-Pyridyl)ethylidine-1,1-bisphosphonate;

NCIt definition : A synthetic pyridinyl bisphosphonate with anti-resorptive activity. Although the exact mechanism of action has yet to be fully elucidated, piridronic acid likely binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, piridronic acid decreases bone turnover and stabilizes the bone matrix.;

UNII : ADD4H8T3K9;

InChIKey : NGMZSXZBZNXBGX-UHFFFAOYSA-N;

CAS number : 75755-07-6;

Chemical formula : C7H11NO6P2;

Details

Origin ID

C66420;

UMLS CUI

C0045686;

Currated CISMeF NLP mapping
- 2-(2-pyridyl)ethylidine-1,1-bisphosphonate [MeSH concept]
- 2-(2-pyridyl)ethylidine-1,1-bisphosphonate [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2-(2-pyridyl)ethylidine-1,1-bisphosphonate [MeSH Supplementary Concept]
- 2-(2-pyridyl)ethylidine-1,1-bisphosphonate [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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