Phenprocoumon - CISMeF

Preferred Label : Phenprocoumon;

NCIt synonyms : 2H-1-Benzopyran-2-one, 4-Hydroxy-3-(1-phenylpropyl)-; 3-(alpha-Phenylpropyl)-4-hydroxycoumarin;

NCIt definition : An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation.;

UNII : Q08SIO485D;

InChIKey : DQDAYGNAKTZFIW-UHFFFAOYSA-N;

CAS number : 435-97-2;

Drug name : Liquamar;

Chemical formula : C18H16O3;

ChEBI ID : CHEBI:50438;

Details

Origin ID

C66374;

UMLS CUI

C0031444;

Automatic exact mappings (from CISMeF team)
- Phenprocoumon [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Phenprocoumon [ICD-11 Extension code]
- Phenprocoumon [LOINC component]
- Phenprocoumon (substance) [SNOMED CT concept]
- phenprocoumon [ATC Code]
- phenprocoumon [Substance BNPC]
- phenprocoumon [MeSH Descriptor]
- phenprocoumon [MeSH concept]
- phenprocoumon [SNOMED Notion]
Validated automatic mappings to BTNT
- phenprocoumon [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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