NCIt definition : A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive
activity. Perindoprilat inhibits ACE and, thus, the conversion of angiotensin I to
angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin
II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis
and natriuresis ensue.;