Parecoxib - CISMeF

Preferred Label : Parecoxib;

NCIt synonyms : Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)-;

NCIt definition : An amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.;

UNII : 9TUW81Y3CE;

InChIKey : TZRHLKRLEZJVIJ-UHFFFAOYSA-N;

CAS number : 198470-84-7;

Chemical formula : C19H18N2O4S;

Details

Origin ID

C66318;

UMLS CUI

C0915142;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Parecoxib (substance) [SNOMED CT concept]
- Product containing parecoxib (medicinal product) [SNOMED CT concept]
- parecoxib [ATC Code]
- parecoxib [MeSH Supplementary Concept]
- parecoxib [MeSH concept]
Validated automatic mappings to BTNT
- parecoxib [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients