Milfasartan - CISMeF

Preferred Label : Milfasartan;

NCIt definition : A nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Milfasartan selectively competes with angiotensin II for the binding of the angiotensin II (AT1) receptor subtype 1 in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex. This blocks the effects of aldosterone leading to an increase in sodium excretion and water and eventually a reduction in plasma volume and blood pressure.;

UNII : 8UAL5421CL;

InChIKey : QVFVAKQHELFATN-UHFFFAOYSA-N;

CAS number : 148564-47-0;

Chemical formula : C30H30N6O3S;

Details

Origin ID

C66152;

UMLS CUI

C1881829;

Currated CISMeF NLP mapping
- milfasartan [MeSH concept]
- milfasartan [MeSH Supplementary Concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- milfasartan [MeSH concept]
- milfasartan [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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