NCIt definition : A nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Milfasartan
selectively competes with angiotensin II for the binding of the angiotensin II (AT1)
receptor subtype 1 in vascular smooth muscle, thereby blocking angiotensin II-mediated
vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect
on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone
synthesis and secretion by the adrenal cortex. This blocks the effects of aldosterone
leading to an increase in sodium excretion and water and eventually a reduction in
plasma volume and blood pressure.;
UNII : 8UAL5421CL;
InChIKey : QVFVAKQHELFATN-UHFFFAOYSA-N;
CAS number : 148564-47-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 148564-47-0
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