" /> Methohexital - CISMeF





Preferred Label : Methohexital;

NCIt synonyms : 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, ( -)-; ( -)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric Acid;

NCIt definition : A rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability, and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.;

UNII : E5B8ND5IPE;

InChIKey : NZXKDOXHBHYTKP-UHFFFAOYSA-N;

CAS number : 151-83-7;

Chemical formula : C14H18N2O3;

ChEBI ID : CHEBI:102216;

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28/07/2025


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