Merimepodib - CISMeF

Preferred Label : Merimepodib;

NCIt synonyms : Carbamic acid, ((3-((((3-methoxy-4-(5-oxazolyl)phenyl)amino)carbonyl)amino)phenyl)methyl)-, (3S)-tetrahydro-3-furanyl ester; MMPD;

NCIt definition : An inosine monophosphate dehydrogenase (IMPDH) inhibitor with activity against hepatitis C virus (HCV). IMPDH catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, and treatment with merimepodib reduces the intracellular guanine nucleotide levels that are required for RNA and DNA synthesis, resulting in antiproliferative and antiviral effect.;

UNII : 2ZL2BA06FU;

InChIKey : JBPUGFODGPKTDW-SFHVURJKSA-N;

CAS number : 198821-22-6;

Molecule name : VX-497; VI-21,497;

Chemical formula : C23H24N4O6;

Details

Origin ID

C66097;

UMLS CUI

C1259637;

Automatic exact mappings (from CISMeF team)
- N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester [MeSH concept]
Currated CISMeF NLP mapping
- N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester [MeSH Supplementary Concept]
- merimepodib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- merimepodib [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Inosine Monophosphate Dehydrogenase [NCIt concept]

Keyword's position in hierarchy(ies) :

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