Preferred Label : Mangafodipir Trisodium;
NCIt definition : The trisodium salt of mangafodipir with potential antioxidant and chemoprotective
activities. Consisting of manganese (II) ions chelated to fodipir (dipyridoxyl diphosphate
or DPDP), mangafodipir scavenges oxygen free radicals such as superoxide anion, hydrogen
peroxide, and hydroxyl radical, potentially preventing oxygen free radical damage
to macromolecules such as DNA and minimizing oxygen free radical-related chemotoxicity
in normal tissues. However, this agent may potentiate the chemotherapy-induced generation
of oxygen free radicals in tumor cells, resulting in the potentiation of chemotherapy-induced
cytotoxicity; tumor cells, with higher levels of reactive oxygen species than normal
cells, possess a lower threshold for oxygen free radical-mediated cytotoxicity. Mangafodipir
is traditionally used as an imaging agent in magnetic resonance imaging (MRI).;
UNII : 129FW80TG4;
InChIKey : BENFPBJLMUIGGD-UHFFFAOYSA-I;
CAS number : 140678-14-4;
Chemical formula : C22H27N4O14P2.Mn.3Na;
Origin ID : C66053;
UMLS CUI : C0067297;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
